Effect of ofatumumab on pregnancy, parturition, and lactation in cynomolgus monkeys.

Bellot, Muriel; Luetjens, C Marc; Bagger, Morten; Horvath, Courtney; Sutter, Esther; DeLise, Anthony; Brees, Dominique; Carballido, José M; Pingili, Ratnakar; Ramanathan, Krishnan; Kieseier, Bernd C; Hellwig, Kerstin

Bellot, Muriel; Luetjens, C Marc; Bagger, Morten; Horvath, Courtney; Sutter, Esther; DeLise, Anthony; Brees, Dominique; Carballido, José M; Pingili, Ratnakar; Ramanathan, Krishnan; Kieseier, Bernd C; Hellwig, Kerstin.

Afiliação

Bellot M; Novartis Institutes for BioMedical Research, Basel, Switzerland. Electronic address: muriel.bellot@novartis.com.
Luetjens CM; Labcorp Early Development Services GmbH, Münster, Germany.
Bagger M; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Horvath C; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Sutter E; Novartis Institutes for BioMedical Research, Basel, Switzerland.
DeLise A; Novartis Pharmaceuticals Corporation, East Hanover, NJ, United States.
Brees D; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Carballido JM; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Pingili R; Novartis Pharma AG, Basel, Switzerland.
Ramanathan K; Novartis Pharma AG, Basel, Switzerland.
Kieseier BC; Novartis Pharma AG, Basel, Switzerland; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Hellwig K; Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany.

Reprod Toxicol ; 108: 28-34, 2022 03.

Article em En | MEDLINE | ID: mdl-34942355

Assuntos

Anticorpos Monoclonais Humanizados/toxicidade; Antineoplásicos/toxicidade; Lactação/efeitos dos fármacos; Parto/efeitos dos fármacos; Administração Intravenosa; Animais; Animais Recém-Nascidos; Anticorpos Monoclonais Humanizados/farmacocinética; Antígenos CD20/imunologia; Antineoplásicos/farmacocinética; Desenvolvimento Embrionário/efeitos dos fármacos; Feminino; Macaca fascicularis; Masculino; Troca Materno-Fetal; Gravidez

Palavras-chave

Anti-CD20; Cynomolgus monkey; Developmental immunotoxicology; Ofatumumab; Pre- and postnatal development

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactação / Parto / Anticorpos Monoclonais Humanizados / Antineoplásicos Limite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Assunto da revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article

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