Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy.

Fernando, Roshini; Caldera, Oshadi; Smith, Terry J

Fernando, Roshini; Caldera, Oshadi; Smith, Terry J.

Afiliação

Fernando R; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105.
Caldera O; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105.
Smith TJ; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105 terrysmi@med.umich.edu.

Proc Natl Acad Sci U S A ; 118(52)2021 12 28.

Article em En | MEDLINE | ID: mdl-34949642

Assuntos

Fibroblastos; Oftalmopatia de Graves/metabolismo; Receptor IGF Tipo 1/antagonistas & inibidores; Anticorpos Monoclonais Humanizados/farmacologia; Autoanticorpos/metabolismo; Células Cultivadas; Citocinas/metabolismo; Fibroblastos/efeitos dos fármacos; Fibroblastos/imunologia; Fibroblastos/metabolismo; Humanos; Receptores da Tireotropina/metabolismo

Palavras-chave

Graves' disease; autoimmune; fibrocyte; thyroid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor IGF Tipo 1 / Oftalmopatia de Graves / Fibroblastos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article

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