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Spitz melanocytic tumours - a review.
Yeh, Iwei; Busam, Klaus J.
Afiliação
  • Yeh I; Department of Dermatology and Pathology, University of California, San Francisco, CA, USA.
  • Busam KJ; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Histopathology ; 80(1): 122-134, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34958498
Spitz tumours comprise a spectrum of melanocytic proliferations that share a set of distinct cytological features and molecular pathways. They include benign naevi, intermediate or indeterminate tumours and rare melanomas. Spitz tumours are notorious for the difficulty of distinguishing benign neoplasms with atypical features from melanomas and the related diagnostic uncertainty. Advances in the knowledge of the molecular pathways and genomic aberrations associated with these neoplasms have permitted opportunities for a reduction in the number of uncertain diagnoses and a more objective distinction between Spitz tumours from Spitz-like neoplasms. The presence of a Spitz molecular pathway, such as Harvey rat sarcoma viral oncogene homologue (HRAS) aberrations or kinase fusions, distinguishes a bona fide Spitz neoplasm from Spitz-like naevi or melanomas with conventional driver mutations. Spitz neoplasms with benign histopathological features and, if such testing is performed, benign cytogenetic and molecular findings, are termed Spitz naevi. Spitz neoplasms with frankly malignant histopathological findings or ambiguous microscopic findings associated with genetic or genomic aberrations most in keeping with melanoma are designated as Spitz melanoma. Tumours with microscopic features and genetic/genomic aberrations in between naevi and melanomas are classified as Spitz melanocytoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Neoplasias Cutâneas / Nevo de Células Epitelioides e Fusiformes / Melanoma Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Histopathology Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Neoplasias Cutâneas / Nevo de Células Epitelioides e Fusiformes / Melanoma Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Histopathology Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos