The idiotypy of auto anti-allotype antibody induced in immunoglobulin allotype suppressed rabbits.
Mol Immunol
; 24(1): 75-82, 1987 Jan.
Article
em En
| MEDLINE
| ID: mdl-3497334
ABSTRACT
Rabbit anti-rabbit idiotype antibody was raised to both clonally heterogeneous and restricted auto anti-b6 antibodies induced in b6 allotype-suppressed (b6)/(b6) homozygous and b4/(b6) heterozygous rabbits. In every case the anti-idiotypic antibodies were specific only for the inducing antibody as shown by direct binding solid-phase RIA. Anti-idiotypes directed to the same antibody preparation had a similar but not identical specificity. It was demonstrated by IEF that the same idiotype specificity (spectrotype) was present throughout the anti-b6 response in individual rabbits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Supressão Genética
/
Anticorpos Anti-Idiotípicos
/
Alótipos de Imunoglobulina
/
Idiótipos de Imunoglobulinas
Limite:
Animals
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
1987
Tipo de documento:
Article