Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of &#945;4ß1 (VLA-4)/&#945;9ß1 Integrin for Therapy of Multiple Sclerosis.

Gilon, Chaim; Klazas, Michal; Lahiani, Adi; Schumacher-Klinger, Adi; Merzbach, Shira; Naoum, Johnny N; Ovadia, Haim; Rubin, Limor; Cornell-Kennon, Susan; Schaefer, Erik M; Katzhendler, Jehoshua; Marcinkiewicz, Cezary; Hoffman, Amnon; Lazarovici, Philip

Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4ß1 (VLA-4)/α9ß1 Integrin for Therapy of Multiple Sclerosis.

Gilon, Chaim; Klazas, Michal; Lahiani, Adi; Schumacher-Klinger, Adi; Merzbach, Shira; Naoum, Johnny N; Ovadia, Haim; Rubin, Limor; Cornell-Kennon, Susan; Schaefer, Erik M; Katzhendler, Jehoshua; Marcinkiewicz, Cezary; Hoffman, Amnon; Lazarovici, Philip.

Afiliação

Gilon C; Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Klazas M; Pharmacy, Pharmacology, and Medicinal Chemistry, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Lahiani A; Pharmacy, Pharmacology, and Medicinal Chemistry, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Schumacher-Klinger A; Pharmacy, Pharmacology, and Medicinal Chemistry, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Merzbach S; Pharmacy, Pharmacology, and Medicinal Chemistry, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Naoum JN; Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Ovadia H; Neurology and Allergy and Clinical Immunology Unit, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Rubin L; Neurology and Allergy and Clinical Immunology Unit, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Cornell-Kennon S; AssayQuant Technologies, Inc., 260 Cedar Hill Street, Marlboro, Massachusetts 01752, United States.
Schaefer EM; AssayQuant Technologies, Inc., 260 Cedar Hill Street, Marlboro, Massachusetts 01752, United States.
Katzhendler J; Pharmacy, Pharmacology, and Medicinal Chemistry, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Marcinkiewicz C; Department of Bioengineering, College of Engineering, Temple University, Philadelphia, Pennsylvania 19122, United States.
Hoffman A; Pharmacy, Pharmacology, and Medicinal Chemistry, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Lazarovici P; Pharmacy, Pharmacology, and Medicinal Chemistry, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

JACS Au ; 1(12): 2361-2376, 2021 Dec 27.

Article em En | MEDLINE | ID: mdl-34977904

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACS Au Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Israel

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