Dashboard-Driven Accelerated Infliximab Induction Dosing Increases Infliximab Durability and Reduces Immunogenicity.

Dubinsky, Marla C; Mendiolaza, Michelle L; Phan, Becky L; Moran, Hunter R; Tse, Stacy S; Mould, Diane R

Dubinsky, Marla C; Mendiolaza, Michelle L; Phan, Becky L; Moran, Hunter R; Tse, Stacy S; Mould, Diane R.

Afiliação

Dubinsky MC; Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mendiolaza ML; Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Phan BL; Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Moran HR; Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tse SS; Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mould DR; Projections Research, Phoenixville PA, USA.

Inflamm Bowel Dis ; 28(9): 1375-1385, 2022 09 01.

Article em En | MEDLINE | ID: mdl-34978325

We present the first proactive infliximab optimization study during induction guided by a pharmacokinetics dashboard in a real-world inflammatory bowel disease setting. At 1 year, clinical outcomes were impacted significantly by the timing of the first maintenance infusion.

Assuntos

Fármacos Gastrointestinais; Doenças Inflamatórias Intestinais; Adolescente; Adulto; Anticorpos; Teorema de Bayes; Proteína C-Reativa; Criança; Monitoramento de Medicamentos/métodos; Fármacos Gastrointestinais/uso terapêutico; Humanos; Doenças Inflamatórias Intestinais/tratamento farmacológico; Infliximab; Estudos Prospectivos

Palavras-chave

PK dashboard; accelerated dosing; infliximab

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Gastrointestinais / Doenças Inflamatórias Intestinais Tipo de estudo: Guideline / Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Child / Humans Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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