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Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells.
Cluff, Emily; Magdaleno, Carina C; Fernandez, Emyly; House, Trenton; Swaminathan, Srividya; Varadaraj, Archana; Rajasekaran, Narendiran.
Afiliação
  • Cluff E; Department of Chemistry and Biochemistry, Northern Arizona University, 700 S Osbourne Drive, Flagstaff, AZ, 86004, USA.
  • Magdaleno CC; Department of Chemistry and Biochemistry, Northern Arizona University, 700 S Osbourne Drive, Flagstaff, AZ, 86004, USA.
  • Fernandez E; Department of Chemistry and Biochemistry, Northern Arizona University, 700 S Osbourne Drive, Flagstaff, AZ, 86004, USA.
  • House T; Department of Chemistry and Biochemistry, Northern Arizona University, 700 S Osbourne Drive, Flagstaff, AZ, 86004, USA.
  • Swaminathan S; Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.
  • Varadaraj A; Department of Chemistry and Biochemistry, Northern Arizona University, 700 S Osbourne Drive, Flagstaff, AZ, 86004, USA.
  • Rajasekaran N; Department of Chemistry and Biochemistry, Northern Arizona University, 700 S Osbourne Drive, Flagstaff, AZ, 86004, USA. naren.raj@nau.edu.
Cancer Immunol Immunother ; 71(8): 1989-2005, 2022 Aug.
Article em En | MEDLINE | ID: mdl-34999917
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Interleucina-2 / Subunidade alfa do Fator 1 Induzível por Hipóxia / Neoplasias Limite: Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Interleucina-2 / Subunidade alfa do Fator 1 Induzível por Hipóxia / Neoplasias Limite: Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos