KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3.

Wang, Yanhong; Li, Na; Zheng, Yanping; Wang, Anqing; Yu, Chunlei; Song, Zhenbo; Wang, Shuyue; Sun, Ying; Zheng, Lihua; Wang, Guannan; Liu, Lei; Yi, Jingwen; Huang, Yanxin; Zhang, Muqing; Bao, Yongli; Sun, Luguo

Wang, Yanhong; Li, Na; Zheng, Yanping; Wang, Anqing; Yu, Chunlei; Song, Zhenbo; Wang, Shuyue; Sun, Ying; Zheng, Lihua; Wang, Guannan; Liu, Lei; Yi, Jingwen; Huang, Yanxin; Zhang, Muqing; Bao, Yongli; Sun, Luguo.

Afiliação

Wang Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Li N; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Zheng Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Wang A; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Yu C; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Song Z; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Wang S; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Sun Y; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Zheng L; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Wang G; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Liu L; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Yi J; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Huang Y; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Zhang M; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Bao Y; School of Molecular and Cellular Biology, University of Illinois Urbana Champaign, Urbana, IL 61801, USA.
Sun L; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.

Int J Mol Sci ; 23(1)2021 Dec 22.

Article em En | MEDLINE | ID: mdl-35008530

Assuntos

Carcinoma Hepatocelular/genética; Transição Epitelial-Mesenquimal/genética; Neoplasias Hepáticas/genética; Invasividade Neoplásica/genética; Fator de Transcrição STAT3/genética; Animais; Carcinoma Hepatocelular/patologia; Linhagem Celular; Linhagem Celular Tumoral; Movimento Celular/genética; Feminino; Regulação Neoplásica da Expressão Gênica/genética; Células HEK293; Células Hep G2; Humanos; Neoplasias Hepáticas/patologia; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Invasividade Neoplásica/patologia; Prognóstico; Ativação Transcricional/genética; Regulação para Cima/genética; Via de Sinalização Wnt/genética; beta Catenina/genética

Palavras-chave

KIAA1217; STAT3; epithelial-mesenchymal transition; hepatocellular carcinoma; metastasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Fator de Transcrição STAT3 / Transição Epitelial-Mesenquimal / Neoplasias Hepáticas / Invasividade Neoplásica Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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