A Single Nucleotide Change in the <i>polC</i> DNA Polymerase III in Clostridium thermocellum Is Sufficient To Create a Hypermutator Phenotype.

Lanahan, Anthony; Zakowicz, Kamila; Tian, Liang; Olson, Daniel G; Lynd, Lee R

A Single Nucleotide Change in the polC DNA Polymerase III in Clostridium thermocellum Is Sufficient To Create a Hypermutator Phenotype.

Lanahan, Anthony; Zakowicz, Kamila; Tian, Liang; Olson, Daniel G; Lynd, Lee R.

Afiliação

Lanahan A; Thayer School of Engineering at Dartmouth Collegegrid.254880.3, Hanover, New Hampshire, USA.
Zakowicz K; Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Tian L; Thayer School of Engineering at Dartmouth Collegegrid.254880.3, Hanover, New Hampshire, USA.
Olson DG; Thayer School of Engineering at Dartmouth Collegegrid.254880.3, Hanover, New Hampshire, USA.
Lynd LR; Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.

Appl Environ Microbiol ; 88(1): e0153121, 2022 01 11.

Article em En | MEDLINE | ID: mdl-35015978

Assuntos

Clostridium thermocellum; Composição de Bases; Clostridium thermocellum/genética; DNA Polimerase III; Nucleotídeos; Fenótipo; Filogenia; RNA Ribossômico 16S; Análise de Sequência de DNA

Palavras-chave

5-FOA; 5-fluoroorotic acid; Acetivibrio thermocellus; Clostridium thermocellum; DNA polymerase III; Hungateiclostridium thermocellum; Ruminiclostridium thermocellum; dnaE; mutation rate; next-generation sequencing; polC; whole-genome sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clostridium thermocellum Tipo de estudo: Prognostic_studies Idioma: En Revista: Appl Environ Microbiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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