Serum levels of lipocalin-2 are elevated at early times in African American relapsing remitting multiple sclerosis patients.
J Neuroimmunol
; 364: 577810, 2022 03 15.
Article
em En
| MEDLINE
| ID: mdl-35066333
ABSTRACT
Previous studies showed that depleting Liver Kinase-B1 (LKB1) from astrocytes increased inflammatory factors lipocalin-2 (LCN2) and osteopontin (OPN) in EAE. A single nucleotide polymorphism (SNP) in STK11 (encoding LKB1) is a risk factor for MS, suggesting increased LCN2 or OPN contributes to risk. Serum LCN2 and OPN levels in African American female MS patients were higher than healthy controls, and while levels increased with disease duration in cases without the SNP, levels decreased with duration in cases with the SNP. Increased MS risk associated with the STK11 SNP may be due to higher LCN2 or OPN levels at early times.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esclerose Múltipla Recidivante-Remitente
/
Lipocalina-2
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Quinases Proteína-Quinases Ativadas por AMP
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos