PKC agonism restricts innate immune suppression, promotes antigen cross-presentation and synergizes with agonistic CD40 antibody therapy to activate CD8<sup>+</sup> T cells in breast cancer.

Chaib, Mehdi; Sipe, Laura M; Yarbro, Johnathan R; Bohm, Margaret S; Counts, Brittany R; Tanveer, Ubaid; Pingili, Ajeeth K; Daria, Deidre; Marion, Tony N; Carson, James A; Thomas, Paul G; Makowski, Liza

PKC agonism restricts innate immune suppression, promotes antigen cross-presentation and synergizes with agonistic CD40 antibody therapy to activate CD8⁺ T cells in breast cancer.

Chaib, Mehdi; Sipe, Laura M; Yarbro, Johnathan R; Bohm, Margaret S; Counts, Brittany R; Tanveer, Ubaid; Pingili, Ajeeth K; Daria, Deidre; Marion, Tony N; Carson, James A; Thomas, Paul G; Makowski, Liza.

Afiliação

Chaib M; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Sipe LM; Department of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Yarbro JR; Department of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Bohm MS; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Counts BR; Division of Regenerative and Rehabilitation Sciences, College of Health Professions, UTHSC Memphis, USA.
Tanveer U; Department of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Pingili AK; Department of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Daria D; Office of Vice Chancellor for Research, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Marion TN; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA; Office of Vice Chancellor for Research, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Carson JA; Division of Regenerative and Rehabilitation Sciences, College of Health Professions, UTHSC Memphis, USA; UTHSC Center for Cancer Research, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Thomas PG; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA; UTHSC Center for Cancer Research, College of Medicine,
Makowski L; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA; Department of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA; Depart

Cancer Lett ; 531: 98-108, 2022 04 10.

Article em En | MEDLINE | ID: mdl-35074498

Assuntos

Neoplasias da Mama; Apresentação Cruzada; Animais; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/metabolismo; Antígenos CD40/metabolismo; Linfócitos T CD8-Positivos; Células Dendríticas; Feminino; Humanos; Imunidade Inata; Camundongos; Microambiente Tumoral

Palavras-chave

CD40; Cross-presentation; DC; MDSC; PKC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Apresentação Cruzada Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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