Unnatural cyclodextrins can be accessed from enzyme-mediated dynamic combinatorial libraries.
Chem Commun (Camb)
; 58(14): 2287-2290, 2022 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-35080533
ABSTRACT
Dynamic systems of cyclodextrins (CDs) enabled by a native cyclodextrin glucanotransferase (CGTase) can incorporate unnatural glucopyranose-derived building blocks, expanding the applicability of enzyme-mediated dynamic combinatorial chemistry by using synthetically modified substrates. Starting dynamic combinatorial libraries from CDs with a single 6-modified glucopyranose results in a dynamic mixture of CDs containing several modified glucopyranoses. The relative concentrations of modified α, ß or γ-CDs can be controlled by the addition of templates, providing a novel way to access modified CDs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclodextrinas
/
Glucosiltransferases
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Dinamarca