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Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy.
Shi, Shi; Du, Yu; Huang, Lei; Cui, Jiaqi; Niu, Jing; Xu, Yungen; Zhu, Qihua.
Afiliação
  • Shi S; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Du Y; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
  • Huang L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Cui J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
  • Niu J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Xu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. Electronic address: xyg@cpu.edu.cn.
  • Zhu Q; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. Electronic address: zhuqihua@vip.126.com.
Bioorg Chem ; 120: 105605, 2022 03.
Article em En | MEDLINE | ID: mdl-35081479
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China