Simvastatin inhibits stem cell proliferation in human leiomyoma via TGF-ß3 and Wnt/ß-Catenin pathways.

Afrin, Sadia; Ali, Mohamed; El Sabeh, Malak; Yang, Qiwei; Al-Hendy, Ayman; Borahay, Mostafa A

Afrin, Sadia; Ali, Mohamed; El Sabeh, Malak; Yang, Qiwei; Al-Hendy, Ayman; Borahay, Mostafa A.

Afiliação

Afrin S; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ali M; Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
El Sabeh M; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yang Q; Department of Gynecology and Obstetrics, University of Chicago School of Medicine, Chicago, Illinois, USA.
Al-Hendy A; Department of Gynecology and Obstetrics, University of Chicago School of Medicine, Chicago, Illinois, USA.
Borahay MA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

J Cell Mol Med ; 26(5): 1684-1698, 2022 03.

Article em En | MEDLINE | ID: mdl-35118811

Assuntos

Leiomioma; Neoplasias Uterinas; Proliferação de Células/genética; Feminino; Humanos; Leiomioma/tratamento farmacológico; Leiomioma/genética; Sinvastatina/farmacologia; Fator de Crescimento Transformador beta3/metabolismo; Neoplasias Uterinas/genética; Neoplasias Uterinas/metabolismo; Neoplasias Uterinas/patologia; beta Catenina/metabolismo

Palavras-chave

TGF-ß3/SMAD2 signalling; Wnt4/ß-catenin signalling; proliferation; simvastatin; stem cell; uterine leiomyoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Leiomioma Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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