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Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase.
Luo, Kaiwen; Chen, Yaohui; Wang, Fan.
Afiliação
  • Luo K; Department of Biology, College of Science, Shantou University, Shantou, China.
  • Chen Y; Department of Biology, College of Science, Shantou University, Shantou, China.
  • Wang F; Department of Biology, College of Science, Shantou University, Shantou, China; wangfan@stu.edu.cn.
J Immunol ; 208(5): 1214-1223, 2022 03 01.
Article em En | MEDLINE | ID: mdl-35149533
ABSTRACT
For a long time, how anti-inflammatory factors evolved was largely unknown. In this study, we chose a marine invertebrate, Litopenaeus vannamei, as a model and identified that shrimp mesencephalic astrocyte-derived neurotrophic factor (MANF) was an LPS-induced plasma protein, which exerted its anti-inflammatory roles on shrimp hemocytes by suppressing ERK phosphorylation and Dorsal expression. In addition, we demonstrated that shrimp MANF could be associated with a receptor protein tyrosine phosphatase (RPTP) to mediate negative regulation of ERK activation and Dorsal expression. More interestingly, shrimp RPTP-S overexpression in 293T cells could switch shrimp and human MANF-mediated ERK pathway activation to inhibition. In general, our results indicate that this conserved RPTP is the key component for extracellular MANF-mediated ERK pathway inhibition, which gives a possible explanation about why this neurotropic factor could both protect neuron cells from apoptosis and inhibit immune cell M1 activation in various species.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Proteína Tirosina Quinases / Penaeidae / MAP Quinases Reguladas por Sinal Extracelular / Fatores de Crescimento Neural / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Proteína Tirosina Quinases / Penaeidae / MAP Quinases Reguladas por Sinal Extracelular / Fatores de Crescimento Neural / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China