Pharmacokinetics of estulic [corrected] in humans.

ABSTRACT

Estulic [corrected] given orally without food after overnight fast produces a blood concentration curve with a pronounced second peak that does not appear when the drug is taken with food. A two-compartment open model involving two different time lags is used to study the pharmacokinetics of estulic [corrected] in humans after oral administration. The drug accumulates in a tissue or organ that is well perfused in the first pass transfer. The accumulation appears to occur by a competitive process. The second peak apparently is the result of a rapid release of drug and bioreversible drug compounds from the hepatic-biliary system with subsequent reabsorption. This release may occur spontaneously, but appears to be triggered by food intake. We use an optimization method to characterize the pharmacokinetic profiles of drug for this model. This technique which provides the global minimum of the deviation delta, from the given observations, leads to the optimization of a single variable function. The results are compared with those obtained from the generalized least squares method.