Short divalent ethacrynic amides as pro-inhibitors of glutathione <i>S</i>-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers.

Xu, Bangtian; Tong, Tingting; Wang, Xin; Liu, Fang; Zhang, Xiang; Hu, Xiaolei; Li, Xinpeng; Yang, Xiaolan; Liao, Fei

Short divalent ethacrynic amides as pro-inhibitors of glutathione S-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers.

Xu, Bangtian; Tong, Tingting; Wang, Xin; Liu, Fang; Zhang, Xiang; Hu, Xiaolei; Li, Xinpeng; Yang, Xiaolan; Liao, Fei.

Afiliação

Xu B; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Tong T; Department of Pharmacy, University-Town Hospital of Chongqing Medical University, Chongqing, China.
Wang X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Liu F; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Zhang X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Hu X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Li X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Yang X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Liao F; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.

J Enzyme Inhib Med Chem ; 37(1): 728-742, 2022 Dec.

Article em En | MEDLINE | ID: mdl-35176963

Assuntos

Antineoplásicos/farmacologia; Cisplatino/farmacologia; Ácido Etacrínico/farmacologia; Etilenodiaminas/farmacologia; Glutationa Transferase/antagonistas & inibidores; Neoplasias Ovarianas/tratamento farmacológico; Putrescina/farmacologia; Animais; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Cisplatino/química; Relação Dose-Resposta a Droga; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Ácido Etacrínico/química; Etilenodiaminas/química; Feminino; Glutationa Transferase/metabolismo; Humanos; Isoenzimas/antagonistas & inibidores; Isoenzimas/metabolismo; Camundongos; Camundongos Nus; Estrutura Molecular; Neoplasias Experimentais/tratamento farmacológico; Neoplasias Experimentais/metabolismo; Neoplasias Experimentais/patologia; Neoplasias Ovarianas/metabolismo; Neoplasias Ovarianas/patologia; Putrescina/química; Relação Estrutura-Atividade

Palavras-chave

Glutathione S-transferase isozyme mu; cisplatin-resistance; divalent pro-inhibitor; sensitisation; slow tight-binding inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Putrescina / Cisplatino / Ácido Etacrínico / Etilenodiaminas / Glutationa Transferase / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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