Overexpression of c-Jun inhibits erastin-induced ferroptosis in Schwann cells and promotes repair of facial nerve function.

Gao, Dekun; Huang, Yuyu; Sun, Xiayu; Yang, Jun; Chen, Jianyong; He, Jingchun

Gao, Dekun; Huang, Yuyu; Sun, Xiayu; Yang, Jun; Chen, Jianyong; He, Jingchun.

Afiliação

Gao D; Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Huang Y; Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China.
Sun X; Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, Shanghai, China.
Yang J; Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Chen J; Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China.
He J; Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, Shanghai, China.

J Cell Mol Med ; 26(8): 2191-2204, 2022 04.

Article em En | MEDLINE | ID: mdl-35191156

Assuntos

Traumatismos do Nervo Facial; Ferroptose; Traumatismos dos Nervos Periféricos; Animais; Nervo Facial/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Piperazinas; Células de Schwann/metabolismo; Transdução de Sinais

Palavras-chave

NRF2/HO-1 pathway; Schwann cells; c-Jun; facial nerve injury; ferroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos do Nervo Facial / Traumatismos dos Nervos Periféricos / Ferroptose Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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