Long-term residential exposure to air pollution and risk of testicular cancer in Denmark: A population-based case-control study.
Cancer Epidemiol Biomarkers Prev
; 2022 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-35191985
ABSTRACT
BACKGROUND:
The incidence rate risk of testicular cancer has increased over the last four decades, and most significant increase has been among Caucasian men in Nordic countries. Second-generation immigrant studies indicate a significant role of environmental exposure in testicular cancer.METHODS:
We conducted a nationwide register-based case-control study, including 6,390 testicular cancer cases registered in the Danish Cancer Registry between 1989 and 2014. Up to four age-matched controls for each case (n=18,997) were randomly selected from Civil Registration System. Ambient air pollution levels were estimated at addresses of cases and controls with a state-of-the-art air pollution modeling system.RESULTS:
We mostly found ORs close to 1.00 and with 95% confidence intervals (CI) spanning 1.00. Exposure during the year preceding birth was associated with ORs for NO2 of 0.87 (95%CI 0.77-0.97) per 10 µg/m3 and for organic carbon of 0.84 (95%CI 0.72-0.98) per 1 µg/m3. Exposure during the first 10 years of life was associated with ORs for organic carbon of 0.79 (95%CI 0.67-0.93) per 1 µg/m3, for O3 of 1.20 (95%CI 1.07-1.34) per 10 µg/m3 and for secondary inorganic aerosols of 1.07 (95%CI 1.00-1.15) per 1 µg/m3.CONCLUSIONS:
Early-life exposure to NO2 and OC was associated with lower risk for testicular cancer whereas early-life exposure to O3 and SIA was associated with higher risk. IMPACT We report both positive and negative associations between ambient air pollutants and risk of testicular, dependent on pollutant, exposure time window and age at diagnosis. This is the first study to investigate such associations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Cancer Epidemiol Biomarkers Prev
Assunto da revista:
BIOQUIMICA
/
EPIDEMIOLOGIA
/
NEOPLASIAS
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Dinamarca