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Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides.
Kohoutova, Zuzana; Malinak, David; Andrys, Rudolf; Svobodova, Jana; Psotka, Miroslav; Schmidt, Monika; Prchal, Lukas; Musilek, Kamil.
Afiliação
  • Kohoutova Z; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Malinak D; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Andrys R; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
  • Svobodova J; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Psotka M; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Schmidt M; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Prchal L; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
  • Musilek K; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
J Enzyme Inhib Med Chem ; 37(1): 760-767, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35193448
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Organofosfatos / Compostos de Piridínio / Compostos de Sulfidrila / Inibidores da Colinesterase Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: República Tcheca
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Organofosfatos / Compostos de Piridínio / Compostos de Sulfidrila / Inibidores da Colinesterase Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: República Tcheca