The methyltransferase enzymes KMT2D, SETD1B, and ASH1L are key mediators of both metabolic and epigenetic changes during cellular senescence.

Nacarelli, Timothy; Azar, Ashley; Potnis, Manali; Johannes, Gregg; Mell, Joshua; Johnson, F Brad; Brown-Borg, Holly; Noguchi, Eishi; Sell, Christian

Nacarelli, Timothy; Azar, Ashley; Potnis, Manali; Johannes, Gregg; Mell, Joshua; Johnson, F Brad; Brown-Borg, Holly; Noguchi, Eishi; Sell, Christian.

Afiliação

Nacarelli T; Glaxosmithkline, Oncology Synthetic Lethal Research Unit, Collegeville, PA 19426.
Azar A; Merck, West Point, PA 19486.
Potnis M; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102.
Johannes G; Absorption Systems LLC, Exton, PA 19341.
Mell J; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129.
Johnson FB; Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104.
Brown-Borg H; Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203.
Noguchi E; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102.
Sell C; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102.

Mol Biol Cell ; 33(5): ar36, 2022 05 01.

Article em En | MEDLINE | ID: mdl-35196069

Assuntos

Senescência Celular; Epigênese Genética; Senescência Celular/genética; Fibroblastos/metabolismo; Glicólise; Metionina/metabolismo; Sirolimo/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Senescência Celular / Epigênese Genética Idioma: En Revista: Mol Biol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article

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