Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/ IL-17/ IL-23 immunoinflammatory pathway.

Abdelrahman, Rehab S; El-Tanbouly, Ghada S

Abdelrahman, Rehab S; El-Tanbouly, Ghada S.

Afiliação

Abdelrahman RS; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madina Al-Munawwarah 30001, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt. Electronic address: Dr_rehabsabri@mans.edu.eg.
El-Tanbouly GS; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt.

Toxicol Appl Pharmacol ; 440: 115931, 2022 04 01.

Article em En | MEDLINE | ID: mdl-35202709

Assuntos

Encefalopatias; Tioacetamida; Animais; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Antioxidantes/metabolismo; Antioxidantes/farmacologia; Encefalopatias/patologia; Hidroxibenzoatos; Interleucina-17/metabolismo; Interleucina-23/metabolismo; Interleucina-23/farmacologia; Interleucina-6/metabolismo; Fígado/metabolismo; Camundongos; Estresse Oxidativo; Serina-Treonina Quinases TOR/metabolismo; Tioacetamida/toxicidade; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

Oxidative stress; Protocatechuic acid; Thioacetamide; mTOR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioacetamida / Encefalopatias Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2022 Tipo de documento: Article

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