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Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne.
Xiao, Na; Xu, Yiru; Zhang, Xinru; Li, Haonan; Zhang, Shengnan; Xiao, Ang; Yu, Jinyi; Yang, Mingtian; Lv, Fujin; Zhang, Mingyu; Hao, Gangping; Chen, Guotong; Zhou, Liman; Kong, Fandong; Pan, Guojun.
Afiliação
  • Xiao N; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agriculture University, Tai'an, China.
  • Xu Y; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Zhang X; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Li H; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Zhang S; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Xiao A; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Yu J; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Yang M; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Lv F; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Zhang M; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Hao G; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Chen G; Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineer
  • Zhou L; Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineer
  • Kong F; Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineer
  • Pan G; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
Front Chem ; 9: 792810, 2021.
Article em En | MEDLINE | ID: mdl-35211458
ABSTRACT
Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research, five new indole-terpenoids (1-5), named encindolenes D-H, were isolated from the fungus Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the anti-diabetic activity assay, compounds 1-5 could inhibit the hepatic glucose production with EC50 values of 17.6, 30.1, 21.3, 9.6, and 9.9 µM, respectively, and decrease the cAMP contents in glucagon-induced HepG2 cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China