Flower essential oil of Tagetes minuta mitigates oxidative stress and restores BDNF-Akt/ERK2 signaling attenuating inflammation- and stress-induced depressive-like behavior in mice.

Birmann, Paloma T; Casaril, Angela M; Zugno, Giuliana P; Acosta, Gabriela G; Severo Sabedra Sousa, Fernanda; Collares, Tiago; Seixas, Fabiana K; Jacob, Raquel G; Brüning, César A; Savegnago, Lucielli; Hartwig, Daniela

Birmann, Paloma T; Casaril, Angela M; Zugno, Giuliana P; Acosta, Gabriela G; Severo Sabedra Sousa, Fernanda; Collares, Tiago; Seixas, Fabiana K; Jacob, Raquel G; Brüning, César A; Savegnago, Lucielli; Hartwig, Daniela.

Afiliação

Birmann PT; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Casaril AM; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Zugno GP; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Acosta GG; Laboratory of Clean Organic Synthesis, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil.
Severo Sabedra Sousa F; Molecular and Cellular Oncology Research Group, Postgraduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Collares T; Molecular and Cellular Oncology Research Group, Postgraduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Seixas FK; Molecular and Cellular Oncology Research Group, Postgraduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Jacob RG; Laboratory of Clean Organic Synthesis, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil.
Brüning CA; Laboratory of Biochemistry and Molecular Neuropharmacology, Postgraduate Program in Biochemistry and Bioprospecting, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil.
Savegnago L; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Hartwig D; Laboratory of Clean Organic Synthesis, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address: daniela.hartwig@ufpel.edu.br.

Brain Res ; 1784: 147845, 2022 06 01.

Article em En | MEDLINE | ID: mdl-35219720

Assuntos

Transtorno Depressivo Maior; Óleos Voláteis; Tagetes; Animais; Comportamento Animal; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Depressão/tratamento farmacológico; Depressão/metabolismo; Transtorno Depressivo Maior/metabolismo; Modelos Animais de Doenças; Flores/metabolismo; Hipocampo/metabolismo; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Camundongos; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Óleos Voláteis/metabolismo; Óleos Voláteis/farmacologia; Óleos Voláteis/uso terapêutico; Estresse Oxidativo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Tagetes/metabolismo

Palavras-chave

BDNF; Depression; Essential oil; Mice; Neurogenesis; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Tagetes / Transtorno Depressivo Maior Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil

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