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A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology.
Guillen, Katrin P; Fujita, Maihi; Butterfield, Andrew J; Scherer, Sandra D; Bailey, Matthew H; Chu, Zhengtao; DeRose, Yoko S; Zhao, Ling; Cortes-Sanchez, Emilio; Yang, Chieh-Hsiang; Toner, Jennifer; Wang, Guoying; Qiao, Yi; Huang, Xiaomeng; Greenland, Jeffery A; Vahrenkamp, Jeffery M; Lum, David H; Factor, Rachel E; Nelson, Edward W; Matsen, Cindy B; Poretta, Jane M; Rosenthal, Regina; Beck, Anna C; Buys, Saundra S; Vaklavas, Christos; Ward, John H; Jensen, Randy L; Jones, Kevin B; Li, Zheqi; Oesterreich, Steffi; Dobrolecki, Lacey E; Pathi, Satya S; Woo, Xing Yi; Berrett, Kristofer C; Wadsworth, Mark E; Chuang, Jeffrey H; Lewis, Michael T; Marth, Gabor T; Gertz, Jason; Varley, Katherine E; Welm, Bryan E; Welm, Alana L.
Afiliação
  • Guillen KP; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Fujita M; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Butterfield AJ; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Scherer SD; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Bailey MH; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Chu Z; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • DeRose YS; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Zhao L; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Cortes-Sanchez E; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Yang CH; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA.
  • Toner J; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Wang G; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Qiao Y; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Huang X; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Greenland JA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Vahrenkamp JM; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Lum DH; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Factor RE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Nelson EW; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Matsen CB; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Poretta JM; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Rosenthal R; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Beck AC; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Buys SS; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Vaklavas C; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA.
  • Ward JH; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA.
  • Jensen RL; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Jones KB; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Li Z; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
  • Oesterreich S; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Dobrolecki LE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Pathi SS; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Woo XY; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
  • Berrett KC; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Wadsworth ME; Department of Surgery, University of Utah, Salt Lake City, UT, USA.
  • Chuang JH; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Lewis MT; Department of Surgery, University of Utah, Salt Lake City, UT, USA.
  • Marth GT; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Gertz J; Department of Surgery, University of Utah, Salt Lake City, UT, USA.
  • Varley KE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Welm BE; Department of Surgery, University of Utah, Salt Lake City, UT, USA.
  • Welm AL; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Nat Cancer ; 3(2): 232-250, 2022 02.
Article em En | MEDLINE | ID: mdl-35221336
Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. We report a bank of human patient-derived xenografts (PDXs) and matched organoid cultures from tumors that represent the greatest unmet need: endocrine-resistant, treatment-refractory and metastatic breast cancers. We leverage matched PDXs and PDX-derived organoids (PDxO) for drug screening that is feasible and cost-effective with in vivo validation. Moreover, we demonstrate the feasibility of using these models for precision oncology in real time with clinical care in a case of triple-negative breast cancer (TNBC) with early metastatic recurrence. Our results uncovered a Food and Drug Administration (FDA)-approved drug with high efficacy against the models. Treatment with this therapy resulted in a complete response for the individual and a progression-free survival (PFS) period more than three times longer than their previous therapies. This work provides valuable methods and resources for functional precision medicine and drug development for human breast cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Nat Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Nat Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos