Synthesis of Functionalized Î´-Hydroxy-ß-keto Esters and Evaluation of Their Anti-inflammatory Properties.

Grosse, Michel; Günther, Kerstin; Jordan, Paul M; Roman, Dávid; Werz, Oliver; Beemelmanns, Christine

Grosse, Michel; Günther, Kerstin; Jordan, Paul M; Roman, Dávid; Werz, Oliver; Beemelmanns, Christine.

Afiliação

Grosse M; Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Beutenbergstrasse 11a, 07745, Jena, Germany.
Günther K; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy - Friedrich-Schiller-University Jena, Philosophenweg 14, 07744, Jena, Germany.
Jordan PM; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy - Friedrich-Schiller-University Jena, Philosophenweg 14, 07744, Jena, Germany.
Roman D; Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Beutenbergstrasse 11a, 07745, Jena, Germany.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy - Friedrich-Schiller-University Jena, Philosophenweg 14, 07744, Jena, Germany.
Beemelmanns C; Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Beutenbergstrasse 11a, 07745, Jena, Germany.

Chembiochem ; 23(9): e202200073, 2022 05 04.

Article em En | MEDLINE | ID: mdl-35244320

Assuntos

Produtos Biológicos; Ésteres; Anti-Inflamatórios/farmacologia; Polienos; Relação Estrutura-Atividade

Palavras-chave

Mukaiyama aldol reaction; diastereoselective reduction; dihydroxy esters; keto esters; statins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Ésteres Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

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