miR-7/TGF-<i>ß2</i> axis sustains acidic tumor microenvironment-induced lung cancer metastasis.

Su, Tao; Huang, Suchao; Zhang, Yanmin; Guo, Yajuan; Zhang, Shuwei; Guan, Jiaji; Meng, Mingjing; Liu, Linxin; Wang, Caiyan; Yu, Dihua; Kwan, Hiu-Yee; Huang, Zhiying; Huang, Qiuju; Lai-Han Leung, Elaine; Hu, Ming; Wang, Ying; Liu, Zhongqiu; Lu, Linlin

miR-7/TGF-ß2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis.

Su, Tao; Huang, Suchao; Zhang, Yanmin; Guo, Yajuan; Zhang, Shuwei; Guan, Jiaji; Meng, Mingjing; Liu, Linxin; Wang, Caiyan; Yu, Dihua; Kwan, Hiu-Yee; Huang, Zhiying; Huang, Qiuju; Lai-Han Leung, Elaine; Hu, Ming; Wang, Ying; Liu, Zhongqiu; Lu, Linlin.

Afiliação

Su T; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Huang S; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Zhang Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Guo Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Zhang S; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Guan J; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Meng M; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Liu L; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Wang C; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Yu D; Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kwan HY; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.
Huang Z; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Huang Q; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Lai-Han Leung E; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR) 999078, China.
Hu M; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA.
Wang Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Liu Z; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Lu L; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR) 999078, China.

Acta Pharm Sin B ; 12(2): 821-837, 2022 Feb.

Article em En | MEDLINE | ID: mdl-35251919

Palavras-chave

AOM/DSS, azoxymethane/dextran sodium sulfate; Acidic tumor microenvironment; B[a]P, benzopyrene; CA9, carbonic anhydrase IX; DAB, diaminobenzidine; DAVID, Database for Annotation, Visualization, and Integrated Discovery; DEGs, differentially expressed genes; DEN, diethylnitrosamine; DEPs, differentially expressed proteins; DSS, dextran sodium sulfate; GEMMs, genetically engineered tumor mouse models; GSEA, gene set enrichment analysis; IHC, immunohistochemistry; ISH, in situ hybridization; Invasion; KEGG, Kyoto Encyclopedia of Genes and Genomes; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; Lung cancer; MCT, monocarboxylate transporter; Metastasis; NHE, Na+/H+ exchanger; NSCLC, non-small cell lung cancer; PCR, polymerase chain reaction; TGF-ß2; TME, tumor microenvironment; TMT, tandem mass tagging; V-ATPase, vacuolar ATPase; miR-7-5p; pH

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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