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Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration.
Vest, Ryan T; Chou, Ching-Chieh; Zhang, Hui; Haney, Michael S; Li, Lulin; Laqtom, Nouf N; Chang, Betty; Shuken, Steven; Nguyen, Andy; Yerra, Lakshmi; Yang, Andrew C; Green, Carol; Tanga, Mary; Abu-Remaileh, Monther; Bassik, Michael C; Frydman, Judith; Luo, Jian; Wyss-Coray, Tony.
Afiliação
  • Vest RT; Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
  • Chou CC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Zhang H; Department of Biology, Stanford University, Stanford, CA 94305.
  • Haney MS; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Li L; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Laqtom NN; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA 94305.
  • Chang B; Palo Alto Veterans Institute for Research, Palo Alto, CA 94304.
  • Shuken S; Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
  • Nguyen A; Institute for Chemistry, Engineering, and Medicine for Human Health, Stanford University, Stanford, CA 94305.
  • Yerra L; Palo Alto Veterans Institute for Research, Palo Alto, CA 94304.
  • Yang AC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Green C; Department of Chemistry, Stanford University, Stanford, CA 94305.
  • Tanga M; Palo Alto Veterans Institute for Research, Palo Alto, CA 94304.
  • Abu-Remaileh M; Palo Alto Veterans Institute for Research, Palo Alto, CA 94304.
  • Bassik MC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Frydman J; SRI International, Menlo Park, CA 94025.
  • Luo J; SRI International, Menlo Park, CA 94025.
  • Wyss-Coray T; Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
Proc Natl Acad Sci U S A ; 119(11): e2121609119, 2022 03 15.
Article em En | MEDLINE | ID: mdl-35259016
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Lisossomos / Anti-Inflamatórios Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Lisossomos / Anti-Inflamatórios Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article