Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-&#954;B signalling pathway.

Zheng, Kenan; Lv, Baojiang; Wu, Lulu; Wang, Chen; Xu, Haoyou; Li, Xiaojun; Wu, Zhibing; Zhao, Yuanqi; Zheng, Zequan

Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway.

Zheng, Kenan; Lv, Baojiang; Wu, Lulu; Wang, Chen; Xu, Haoyou; Li, Xiaojun; Wu, Zhibing; Zhao, Yuanqi; Zheng, Zequan.

Afiliação

Zheng K; The First Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lv B; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wu L; The First Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wang C; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xu H; The First Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Li X; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wu Z; Department of Traditional Chinese Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhao Y; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China.
Zheng Z; The Second Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, China.

Bioengineered ; 13(4): 9322-9344, 2022 04.

Article em En | MEDLINE | ID: mdl-35287559

Assuntos

Emodina; Encefalomielite Autoimune Experimental; Animais; Anti-Inflamatórios/metabolismo; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Emodina/metabolismo; Emodina/farmacologia; Emodina/uso terapêutico; Encefalomielite Autoimune Experimental/tratamento farmacológico; Encefalomielite Autoimune Experimental/patologia; Inflamação/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Microglia/metabolismo; Microglia/patologia; Simulação de Acoplamento Molecular; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Medula Espinal/metabolismo; Medula Espinal/patologia

Palavras-chave

MS/EAE; PI3K/AKT/NF- κB signalling pathway; TLRs/MyD88 signal; emodin; microglia activation; myelin protective; network pharmacology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Emodina / Encefalomielite Autoimune Experimental Limite: Animals Idioma: En Revista: Bioengineered Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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