AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.

Bourner, Luke A; Muro, Israel; Cooper, Amy M; Choudhury, Barun K; Bailey, Aaron O; Russell, William K; Khanipov, Kamil; Golovko, George; Wright, Casey W

Bourner, Luke A; Muro, Israel; Cooper, Amy M; Choudhury, Barun K; Bailey, Aaron O; Russell, William K; Khanipov, Kamil; Golovko, George; Wright, Casey W.

Afiliação

Bourner LA; Department of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Muro I; Toxicology Training Program, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Cooper AM; Department of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Choudhury BK; Department of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Bailey AO; Toxicology Training Program, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Russell WK; Department of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Khanipov K; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Golovko G; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Wright CW; Department of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555.

Proc Natl Acad Sci U S A ; 119(12): e2114336119, 2022 03 22.

Article em En | MEDLINE | ID: mdl-35290121

Assuntos

Translocador Nuclear Receptor Aril Hidrocarboneto; Neoplasias; Translocador Nuclear Receptor Aril Hidrocarboneto/genética; Translocador Nuclear Receptor Aril Hidrocarboneto/metabolismo; Fatores de Transcrição Hélice-Alça-Hélice Básicos; Humanos; Ligantes; Fosforilação; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Receptores de Hidrocarboneto Arílico/genética; Receptores de Hidrocarboneto Arílico/metabolismo; Linfócitos T/metabolismo

Palavras-chave

ARNT; AhR; immunomodulation; isoform

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocador Nuclear Receptor Aril Hidrocarboneto / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article

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