Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and ß-TrCP in the ubiquitin-proteasome pathway.

Gong, Rui-Hong; Chen, Minting; Huang, Chunhua; Wong, Hoi Leong Xavier; Kwan, Hiu Yee; Bian, Zhaoxiang

Gong, Rui-Hong; Chen, Minting; Huang, Chunhua; Wong, Hoi Leong Xavier; Kwan, Hiu Yee; Bian, Zhaoxiang.

Afiliação

Gong RH; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Chen M; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Huang C; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Wong HLX; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Kwan HY; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China. hykwan@hkbu.edu.hk.
Bian Z; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China. bzxiang@hkbu.edu.hk.

Cell Commun Signal ; 20(1): 34, 2022 03 19.

Article em En | MEDLINE | ID: mdl-35305671

Assuntos

Ubiquitina-Proteína Ligases; Proteínas Contendo Repetições de beta-Transducina; Animais; Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase/metabolismo; Artesunato/farmacologia; Linhagem Celular Tumoral; Proteínas Culina; Glicogênio Sintase Quinase 3 beta/metabolismo; Humanos; Camundongos; Fosfatidilinositol 3-Quinases/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteólise; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Pirazinas; Piridinas; Serina-Treonina Quinases TOR/metabolismo; Enzimas de Conjugação de Ubiquitina; Ubiquitina-Proteína Ligases/metabolismo; Ubiquitinas/metabolismo; Via de Sinalização Wnt; Proteínas Contendo Repetições de beta-Transducina/genética; Proteínas Contendo Repetições de beta-Transducina/metabolismo

Palavras-chave

Artesunate; Colorectal cancer; Combination treatment; KRAS; Protein degradation; WNT974

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases / Proteínas Contendo Repetições de beta-Transducina Limite: Animals / Humans Idioma: En Revista: Cell Commun Signal Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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