Better, Faster, Cheaper: Recent Advances in Cryo-Electron Microscopy.
Annu Rev Biochem
; 91: 1-32, 2022 06 21.
Article
em En
| MEDLINE
| ID: mdl-35320683
ABSTRACT
Cryo-electron microscopy (cryo-EM) continues its remarkable growth as a method for visualizing biological objects, which has been driven by advances across the entire pipeline. Developments in both single-particle analysis and in situ tomography have enabled more structures to be imaged and determined to better resolutions, at faster speeds, and with more scientists having improved access. This review highlights recent advances at each stageof the cryo-EM pipeline and provides examples of how these techniques have been used to investigate real-world problems, including antibody development against the SARS-CoV-2 spike during the recent COVID-19 pandemic.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pandemias
/
COVID-19
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2022
Tipo de documento:
Article