Ancestry adjustment improves genome-wide estimates of regional intolerance.
Genetics
; 221(2)2022 05 31.
Article
em En
| MEDLINE
| ID: mdl-35385101
ABSTRACT
Genomic regions subject to purifying selection are more likely to carry disease-causing mutations than regions not under selection. Cross species conservation is often used to identify such regions but with limited resolution to detect selection on short evolutionary timescales such as that occurring in only one species. In contrast, genetic intolerance looks for depletion of variation relative to expectation within a species, allowing species-specific features to be identified. When estimating the intolerance of noncoding sequence, methods strongly leverage variant frequency distributions. As the expected distributions depend on ancestry, if not properly controlled for, ancestral population source may obfuscate signals of selection. We demonstrate that properly incorporating ancestry in intolerance estimation greatly improved variant classification. We provide a genome-wide intolerance map that is conditional on ancestry and likely to be particularly valuable for variant prioritization.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Genômica
Limite:
Humans
Idioma:
En
Revista:
Genetics
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos