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Efficacy of liraglutide in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials.
Mali, Niroj; Su, Feng; Ge, Jie; Fan, Wen Xing; Zhang, Jing; Ma, Jingyuan.
Afiliação
  • Mali N; Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
  • Su F; Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
  • Ge J; Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
  • Fan WX; Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China. fanwx2020@163.com.
  • Zhang J; NHC Key Laboratory of Drug Addiction Medicine, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China. fanwx2020@163.com.
  • Ma J; Department of Nutrition, the First Affiliated Hospital of Kunming Medical University, No.295, Xichang Road, Kunming, 650032, Yunnan Province, China. fanwx2020@163.com.
BMC Endocr Disord ; 22(1): 93, 2022 Apr 07.
Article em En | MEDLINE | ID: mdl-35392872
ABSTRACT

BACKGROUND:

The efficacy of liraglutide to treat type 2 diabetic nephropathy (T2DN) remains controversial. Thus, we conducted this meta-analysis to systematically evaluate the clinical effect of liraglutide on T2DN patients.

METHODS:

Eight databases (PubMed, Web of Science, the Cochrane Library, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, China Science and Technology Journal Database, and China Biology Medicine Database (CBM)) were searched for published articles to evaluate the clinical efficacy of liraglutide in subjects with T2DN. The Revman 5.3 and Stata 13 software were used for analyses and plotting.

RESULTS:

A total of 18 randomized controlled trials (RCTs) with 1580 diabetic nephropathy patients were screened. We found that the levels of UACR, Scr, Cysc were lower in the experimental group of T2DN patients treated with liraglutide than in the control group intervened without liraglutide. Liraglutide also reduced the levels of blood glucose (including FBG, PBG, and HbA1c), body mass index (BMI), and anti-inflammatory indicators (TNF-α, IL-6). However, there was no significant difference in BUN and eGFR between the experimental group and the control group.

CONCLUSIONS:

Liraglutide reduced the levels of Blood Glucose, BMI, renal outcome indicators, and serum inflammatory factors of patients with T2DN, suggesting the beneficial effects of liraglutide on renal function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Humans Idioma: En Revista: BMC Endocr Disord Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Humans Idioma: En Revista: BMC Endocr Disord Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China