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Bone Penetration of Cycloserine in Osteoarticular Tuberculosis Patients of China.
Zhang, Tingting; Yu, Xia; Wen, Shu'an; Xue, Yi; Xiao, Hua; Ren, Ruyan; Wang, Fen; Dong, Lingling; Qin, Shibing; Huang, Hairong.
Afiliação
  • Zhang T; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Yu X; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Wen S; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Xue Y; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Xiao H; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Ren R; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Wang F; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Dong L; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Qin S; Department of Orthopedics, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing, China.
  • Huang H; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
Antimicrob Agents Chemother ; 66(5): e0222421, 2022 05 17.
Article em En | MEDLINE | ID: mdl-35400177
ABSTRACT
The cycloserine concentrations in plasma and bone that were collected during operations on 28 osteoarticular tuberculosis (TB) patients treated daily with a 500-mg cycloserine-containing regimen were determined. The median concentrations in plasma and bone were 16.29 µg/mL (interquartile range [IQR], 6.47 µg/mL) and 24.33 µg/g (IQR, 14.68 µg/g), respectively. The median bone/plasma penetration ratio was 0.76 (range, 0.33 to 1.98). Cycloserine could effectively penetrate bone and acquire concentrations comparable to those in plasma, which favors its usage in osteoarticular TB treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Osteoarticular / Tuberculose Resistente a Múltiplos Medicamentos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Osteoarticular / Tuberculose Resistente a Múltiplos Medicamentos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China