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Nitric oxide and skeletal muscle contractile function.
Kumar, Ravi; Coggan, Andrew R; Ferreira, Leonardo F.
Afiliação
  • Kumar R; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
  • Coggan AR; Department of Kinesiology, Indiana University Purdue University, Indianapolis, IN, USA. Electronic address: acoggan@iupui.edu.
  • Ferreira LF; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Physiology, Amsterdam UMC Locatie VUmc, Amsterdam, the Netherlands. Electronic address: ferreira@hhp.ufl.edu.
Nitric Oxide ; 122-123: 54-61, 2022 05 01.
Article em En | MEDLINE | ID: mdl-35405336
ABSTRACT
Nitric oxide (NO) is complex modulator of skeletal muscle contractile function, capable of increasing or decreasing force and power output depending on multiple factors. This review explores the effects and potential mechanisms for modulation of skeletal muscle contractile function by NO, from pharmacological agents in isolated muscle preparations to dietary nitrate supplementation in humans and animals. Pharmacological manipulation in vitro suggests that NO signaling diminishes submaximal isometric force, whereas dietary manipulation in vivo suggest that NO enhances submaximal force. The bases for these different responses are unknown but could reflect dose-dependent effects. Maximal isometric force is unaffected by physiologically relevant levels of NO, which do not induce overt protein oxidation. Pharmacological and dietary manipulation of NO signaling enhances the maximal rate of isometric force development, unloaded shortening velocity, and peak power. We hypothesize that these effects are mediated by post-translational modifications of myofibrillar proteins that modulate thick filament regulation of contraction (e.g., mechanosensing and strain-dependence of cross-bridge kinetics). NO effects on contractile function appear to have some level of fiber type and sex-specificity. The mechanisms behind NO-mediated changes in skeletal muscle function need to be explored through proteomics analysis and advanced biophysical assays to advance the development of small molecules and open intriguing therapeutic and ergogenic possibilities for aging, disease, and athletic performance.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Contração Muscular / Óxido Nítrico Limite: Animals Idioma: En Revista: Nitric Oxide Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Contração Muscular / Óxido Nítrico Limite: Animals Idioma: En Revista: Nitric Oxide Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos