The perfect PTEN - transcriptional regulation by PTEN dictates sarcoma identity.
Mol Cell Oncol
; 8(6): 2002120, 2021.
Article
em En
| MEDLINE
| ID: mdl-35419479
ABSTRACT
Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell identity. These results highlight the importance between transcriptional state, cell of origin, and genetic perturbation in tumorigenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos