Monoclonal antibodies from B cells of patients with anti-MDA5 antibody-positive dermatomyositis directly stimulate interferon gamma production.

Coutant, Frédéric; Bachet, Rafael; Pin, Jean-Jacques; Alonzo, Marina; Miossec, Pierre

Coutant, Frédéric; Bachet, Rafael; Pin, Jean-Jacques; Alonzo, Marina; Miossec, Pierre.

Afiliação

Coutant F; Immunogenomics and Inflammation Research Team, University of Lyon, Edouard Herriot Hospital, Lyon, France; Immunology Department, Lyon-Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France. Electronic address: frederic.coutant@univ-lyon.1.fr.
Bachet R; Immunogenomics and Inflammation Research Team, University of Lyon, Edouard Herriot Hospital, Lyon, France.
Pin JJ; Eurobio Scientific/Dendritics - Edouard Herriot Hospital, Lyon, France.
Alonzo M; Immunogenomics and Inflammation Research Team, University of Lyon, Edouard Herriot Hospital, Lyon, France.
Miossec P; Immunogenomics and Inflammation Research Team, University of Lyon, Edouard Herriot Hospital, Lyon, France; Department of Immunology and Rheumatology, Edouard Herriot Hospital, Lyon, France.

J Autoimmun ; 130: 102831, 2022 06.

Article em En | MEDLINE | ID: mdl-35436746

Assuntos

Anticorpos Monoclonais; Dermatomiosite; Interferon gama; Anticorpos Monoclonais/imunologia; Autoanticorpos; Linfócitos B; Dermatomiosite/imunologia; Humanos; Interferon gama/metabolismo

Palavras-chave

Amyopathic dermatomyositis; Autoantibody; CADM-140; Dermatomyositis; Human monoclonal antibody; IFN-Gamma; Idiopathic inflammatory myopathies; MDA5; Monocytes; Myositis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon gama / Dermatomiosite / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Autoimmun Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article

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