SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-ß oligomers.

Norambuena, Andrés; Sun, Xuehan; Wallrabe, Horst; Cao, Ruofan; Sun, Naidi; Pardo, Evelyn; Shivange, Nutan; Wang, Dora Bigler; Post, Lisa A; Ferris, Heather A; Hu, Song; Periasamy, Ammasi; Bloom, George S

Norambuena, Andrés; Sun, Xuehan; Wallrabe, Horst; Cao, Ruofan; Sun, Naidi; Pardo, Evelyn; Shivange, Nutan; Wang, Dora Bigler; Post, Lisa A; Ferris, Heather A; Hu, Song; Periasamy, Ammasi; Bloom, George S.

Afiliação

Norambuena A; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA. Electronic address: an2r@virginia.edu.
Sun X; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Wallrabe H; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Cao R; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA; W.M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904, USA.
Sun N; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Pardo E; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Shivange N; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Wang DB; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Post LA; Department of Neuroscience, University of Virginia, Charlottesville, VA 22904, USA; Division of Endocrinology & Metabolism, School of Medicine, University of Virginia, Charlottesville, VA 22904, USA.
Ferris HA; Department of Neuroscience, University of Virginia, Charlottesville, VA 22904, USA; Division of Endocrinology & Metabolism, School of Medicine, University of Virginia, Charlottesville, VA 22904, USA.
Hu S; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Periasamy A; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA; W.M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904, USA.
Bloom GS; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA; Department of Cell Biology, University of Virginia, Charlottesville, VA 22904, USA; Department of Neuroscience, University of Virginia, Charlottesville, VA 22904, USA.

Neurobiol Dis ; 169: 105737, 2022 07.

Article em En | MEDLINE | ID: mdl-35452786

Assuntos

Doença de Alzheimer; Peptídeos beta-Amiloides; Superóxido Dismutase-1; Esclerose Tuberosa; Doença de Alzheimer/enzimologia; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/genética; Peptídeos beta-Amiloides/metabolismo; Animais; DNA Mitocondrial/genética; DNA Mitocondrial/metabolismo; Humanos; Lisossomos/genética; Lisossomos/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Camundongos; Mitocôndrias/metabolismo; Superóxido Dismutase-1/genética; Superóxido Dismutase-1/metabolismo; Esclerose Tuberosa/enzimologia; Esclerose Tuberosa/genética

Palavras-chave

Alzheimer's disease; Amino acids; Insulin; Tau; mTOR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Tuberosa / Peptídeos beta-Amiloides / Doença de Alzheimer / Superóxido Dismutase-1 Limite: Animals / Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article

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