Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human &#945;-synuclein transgenic mice.

Lloyd, Grace M; Sorrentino, Zachary A; Quintin, Stephan; Gorion, Kimberly-Marie M; Bell, Brach M; Paterno, Giavanna; Long, Brooke; Prokop, Stefan; Giasson, Benoit I

Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice.

Lloyd, Grace M; Sorrentino, Zachary A; Quintin, Stephan; Gorion, Kimberly-Marie M; Bell, Brach M; Paterno, Giavanna; Long, Brooke; Prokop, Stefan; Giasson, Benoit I.

Afiliação

Lloyd GM; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Sorrentino ZA; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Quintin S; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Gorion KM; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Bell BM; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Paterno G; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Long B; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Prokop S; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Giasson BI; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

Acta Neuropathol ; 143(6): 663-685, 2022 06.

Article em En | MEDLINE | ID: mdl-35488930

Assuntos

Doença de Alzheimer; Atrofia de Múltiplos Sistemas; Príons; Sinucleinopatias; Doença de Alzheimer/patologia; Amiloide; Animais; Humanos; Camundongos; Camundongos Transgênicos; Atrofia de Múltiplos Sistemas/patologia; Príons/genética; Príons/metabolismo; Sinucleinopatias/genética; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo

Palavras-chave

Alzheimer's disease with amygdala predominant Lewy bodies; Amyloid; Dementia with Lewy bodies; Multiple system atrophy; Prion; Strains; Synucleinopathy; α-synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Príons / Atrofia de Múltiplos Sistemas / Doença de Alzheimer / Sinucleinopatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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