Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase.

Kaur, Supreet; Nieto, Nicholas S; McDonald, Peter; Beck, Josh R; Honzatko, Richard B; Roy, Anuradha; Nelson, Scott W

Kaur, Supreet; Nieto, Nicholas S; McDonald, Peter; Beck, Josh R; Honzatko, Richard B; Roy, Anuradha; Nelson, Scott W.

Afiliação

Kaur S; Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
Nieto NS; Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
McDonald P; High Throughput Screening Laboratory, University of Kansas, Lawrence, KS, USA.
Beck JR; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Honzatko RB; Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
Roy A; High Throughput Screening Laboratory, University of Kansas, Lawrence, KS, USA.
Nelson SW; Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.

J Enzyme Inhib Med Chem ; 37(1): 1320-1326, 2022 Dec.

Article em En | MEDLINE | ID: mdl-35514163

Assuntos

Antimaláricos; Apicoplastos; Malária; Antimaláricos/farmacologia; Apicoplastos/genética; DNA; DNA Polimerase Dirigida por DNA; Humanos; Plasmodium falciparum; Proteínas de Protozoários/genética

Palavras-chave

DNA polymerase; Malaria; apicoplast; high-throughput screening

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apicoplastos / Malária / Antimaláricos Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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