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N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction.
Gabe, Maria Buur Nordskov; Gasbjerg, Laerke Smidt; Gadgaard, Sarina; Lindquist, Peter; Holst, Jens Juul; Rosenkilde, Mette Marie.
Afiliação
  • Gabe MBN; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gasbjerg LS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gadgaard S; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lindquist P; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Holst JJ; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Rosenkilde MM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Br J Pharmacol ; 179(18): 4473-4485, 2022 09.
Article em En | MEDLINE | ID: mdl-35523760
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo 1 Semelhante ao Glucagon / Receptor do Peptídeo Semelhante ao Glucagon 1 Limite: Animals / Humans Idioma: En Revista: Br J Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo 1 Semelhante ao Glucagon / Receptor do Peptídeo Semelhante ao Glucagon 1 Limite: Animals / Humans Idioma: En Revista: Br J Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Dinamarca