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Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.
Zorbaz, Tamara; Malinak, David; Hofmanova, Tereza; Marakovic, Nikola; Zunec, Suzana; Hrvat, Nikolina Macek; Andrys, Rudolf; Psotka, Miroslav; Zandona, Antonio; Svobodova, Jana; Prchal, Lukas; Fingler, Sanja; Katalinic, Maja; Kovarik, Zrinka; Musilek, Kamil.
Afiliação
  • Zorbaz T; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia.
  • Malinak D; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005, Hradec Kralove, Czech Republic.
  • Hofmanova T; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.
  • Marakovic N; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia.
  • Zunec S; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia.
  • Hrvat NM; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia.
  • Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.
  • Psotka M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005, Hradec Kralove, Czech Republic.
  • Zandona A; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia.
  • Svobodova J; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.
  • Prchal L; Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005, Hradec Kralove, Czech Republic.
  • Fingler S; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia.
  • Katalinic M; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia.
  • Kovarik Z; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, HR-10000, Zagreb, Croatia. Electronic address: zkovarik@imi.hr.
  • Musilek K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005, Hradec Kralove, Czech Republic. Electronic address: kamil.musilek@uhk.cz.
Eur J Med Chem ; 238: 114377, 2022 Aug 05.
Article em En | MEDLINE | ID: mdl-35526478
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reativadores da Colinesterase / Agentes Neurotóxicos Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Croácia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reativadores da Colinesterase / Agentes Neurotóxicos Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Croácia