Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study.
Environ Health
; 21(1): 52, 2022 05 12.
Article
em En
| MEDLINE
| ID: mdl-35549707
ABSTRACT
BACKGROUND:
While benefits of greenness to health have been reported, findings specific to child respiratory health are inconsistent.METHODS:
We utilized a prospective birth cohort followed from birth to age 7 years (n = 617). Residential surrounding greenness was quantified via Normalized Difference Vegetation Index (NDVI) within 200, 400, and 800 m distances from geocoded home addresses at birth, age 7 years, and across childhood. Respiratory health outcomes were assessed at age 7 years, including asthma and lung function [percent predicted forced expiratory volume in the first second (%FEV1), percent predicted forced vital capacity (%FVC), and percent predicted ratio of forced expiratory volume in the first second to forced vital capacity (%FEV1/FVC)]. We assessed associations using linear and logistic regression models adjusted for community deprivation, household income, and traffic-related air pollution. We tested for effect measure modification by atopic status.RESULTS:
We noted evidence of positive confounding as inverse associations were attenuated upon adjustment in the multivariable models. We found evidence of effect measure modification of NDVI and asthma within 400 m at age 7 years by atopic status (p = 0.04), whereby children sensitized to common allergens were more likely to develop asthma as exposure to greenness increased (OR = 1.3, 95% CI 0.9, 2.0) versus children not sensitized to common allergens (OR = 0.8, 95% CI 0.5, 1.2). We found consistently positive associations between NDVI and %FEV1 and %FVC which similarly evidenced positive confounding upon adjustment. In the adjusted regression models, NDVI at 7 years of age was associated with %FEV1 (200 m ß = 2.1, 95% CI 0.1, 3.3; 400 m ß = 1.6, 95% CI 0.3, 2.9) and %FVC (200 m ß = 1.8, 95% CI 0.7, 3.0; 400 m ß = 1.6, 95% CI 0.3, 2.8; 800 m ß = 1.5, 95% CI 0.1, 2.8). Adjusted results for %FEV1/FVC were non-significant except exposure at birth in the 400 m buffer (ß = 0.81, 95% CI 0.1, 1.5). We found no evidence of effect measure modification of NDVI by atopic status for objective measures of lung function.CONCLUSION:
Sensitivity to allergens may modify the effect of greenness on risk for asthma in children but greenness is likely beneficial for concurrent lung function regardless of allergic status.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Poluição do Ar
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
/
Newborn
Idioma:
En
Revista:
Environ Health
Assunto da revista:
SAUDE AMBIENTAL
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos