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Development of a potent small-molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation.
Ohoka, Nobumichi; Suzuki, Masanori; Uchida, Takuya; Tsukumo, Yoshinori; Yoshida, Masayuki; Inoue, Takao; Ohki, Hitoshi; Naito, Mikihiko.
Afiliação
  • Ohoka N; Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
  • Suzuki M; Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Uchida T; Medicinal Chemistry Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Tsukumo Y; Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
  • Yoshida M; Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Inoue T; Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
  • Ohki H; Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Naito M; Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Cancer Sci ; 113(8): 2828-2838, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35579105
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Melanoma Limite: Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Melanoma Limite: Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão