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A SARS-CoV-2 outbreak associated with vaccine breakthrough in an acute care hospital.
Park, Se Yoon; Kim, Tae Hyong; Lee, Eunjung; Loeb, Mark; Jeong, Yeon Su; Kim, Jin Hwa; Oh, Sun Mi; Cheong, Sojin; Park, Hyein; Jo, SoYea; Sim, Ji Woo.
Afiliação
  • Park SY; Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea; Department of Hospital Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea; Centers for Digital
  • Kim TH; Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. Electronic address: geuncom@schmc.ac.kr.
  • Lee E; Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
  • Loeb M; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario Canada.
  • Jeong YS; Infection Control Team, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • Kim JH; Infection Control Team, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • Oh SM; Infection Control Team, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • Cheong S; Infection Control Team, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • Park H; Infection Control Team, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • Jo S; Infection Control Team, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • Sim JW; Infectious Disease Control Division, Seoul Metropolitan Government, Seoul, Korea.
Am J Infect Control ; 50(9): 1006-1012, 2022 09.
Article em En | MEDLINE | ID: mdl-35605754
BACKGROUND: We aimed to analyze an outbreak caused by a vaccine breakthrough infection in a hospital with an active infection control program where 91.9% of health care workers were vaccinated. METHODS: We investigated a SARS-CoV-2 outbreak between September 9 and October 2, 2021, in a referral teaching hospital in Korea. We retrospectively collected data on demographics, vaccination history, transmission, and clinical features of confirmed coronavirus disease 2019 (COVID-19) in patients, health care workers, and caregivers. RESULTS: During the outbreak, 94 individuals tested positive for SARS-CoV-2 using reverse transcription-polymerase chain reaction testing. There were infections in 61 health care workers, 18 patients, and 15 caregivers; 74.5% (70/94) were vaccine breakthrough infections. Most transmissions appeared to be caused by three index cases, which accounted for 86.2% (81/94) of transmissions. Forty-seven (58.0%, 47/81) cases were associated with the hospital staff cafeteria and offices located in the basement. Among health care workers and caregivers, only one required oxygen supplementation. In contrast, among patients, there were four fatal cases (22.2%, 4/18), 3 of which were unvaccinated. CONCLUSIONS: Superspreading infection among fully vaccinated individuals occurred in an acute care hospital while the delta variant was dominant. Given the potential for severe complications, as this outbreak demonstrated, preventive measures including adequate ventilation should be emphasized to minimize transmission in hospitals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / COVID-19 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Am J Infect Control Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / COVID-19 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Am J Infect Control Ano de publicação: 2022 Tipo de documento: Article