Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities.
J Fungi (Basel)
; 8(5)2022 May 23.
Article
em En
| MEDLINE
| ID: mdl-35628798
ABSTRACT
Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytochalasans (1-7), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds 1-3 and 8-11 exhibited antimigratory effects against MDA-MB-231 in vitro with IC50 values in the range of 1.01-10.42 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Fungi (Basel)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China