Polyphosphoramidates That Undergo Acid-Triggered Backbone Degradation.
ACS Macro Lett
; 6(3): 219-223, 2017 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-35650917
ABSTRACT
The direct and facile synthesis of polyphosphoramidates (PPAs) with acid-labile phosphoramidate backbone linkages are reported, together with demonstration of their hydrolytic degradability, evaluated under acidic conditions. The introduction of acid-labile linkages along the polymer backbone led to rapid degradation of the polymer backbone dependent upon the environmental stimuli. An oxazaphospholidine monomer bearing a phosphoramidate linkage was designed and synthesized to afford the PPAs via organobase-catalyzed ring-opening polymerization in a controlled manner. The hydrolytic degradation of the PPAs was studied, revealing breakdown of the polymer backbone through cleavage of the phosphoramidate linkages under acidic conditions.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
ACS Macro Lett
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos