Total Synthesis and Prediction of Ulodione Natural Products Guided by DFT Calculations.
Angew Chem Int Ed Engl
; 61(32): e202207004, 2022 08 08.
Article
em En
| MEDLINE
| ID: mdl-35670364
ABSTRACT
A biomimetic synthetic strategy has resulted in a two-step total synthesis of (±)-ulodioneâ
A and the prediction of two potential natural products, (±)-ulodionesâ
C and D. This work was guided by computational investigations into the selectivity of a proposed biosynthetic Diels-Alder dimerization, which was then utilized in the chemical synthesis. This work highlights how biosynthetic considerations can both guide the design of efficient synthetic strategies and lead to the anticipation of new natural products.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Reino Unido