HLA-I diversity and tumor mutational burden by comprehensive next-generation sequencing as predictive biomarkers for the treatment of non-small cell lung cancer with PD-(L)1 inhibitors.

Cuppens, Kristof; Baas, Paul; Geerdens, Ellen; Cruys, Bert; Froyen, Guy; Decoster, Lynn; Thomeer, Michiel; Maes, Brigitte

Cuppens, Kristof; Baas, Paul; Geerdens, Ellen; Cruys, Bert; Froyen, Guy; Decoster, Lynn; Thomeer, Michiel; Maes, Brigitte.

Afiliação

Cuppens K; Dept. Pulmonology and Thoracic Oncology, Jessa Hospital, Hasselt, Belgium; Dept. Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Faculty of Medicine and Life Sciences - LCRC, Hasselt University, Diepenbeek, Belgium. Electronic address: Kristof.cuppens@jessazh.be.
Baas P; Dept. Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Geerdens E; Laboratory for Molecular Diagnostics, Dept Laboratory Medicine, Jessa Hospital, Hasselt, Belgium.
Cruys B; Laboratory for Molecular Diagnostics, Dept Laboratory Medicine, Jessa Hospital, Hasselt, Belgium.
Froyen G; Laboratory for Molecular Diagnostics, Dept Laboratory Medicine, Jessa Hospital, Hasselt, Belgium.
Decoster L; Dept. Pulmonology, AZ Turnhout, Turnhout, Belgium.
Thomeer M; Faculty of Medicine and Life Sciences - LCRC, Hasselt University, Diepenbeek, Belgium; Dept. Respiratory Medicine, Ziekenhuis Oost Limburg, Genk, Belgium.
Maes B; Laboratory for Molecular Diagnostics, Dept Laboratory Medicine, Jessa Hospital, Hasselt, Belgium.

Lung Cancer ; 170: 1-10, 2022 08.

Article em En | MEDLINE | ID: mdl-35689896

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Antígeno B7-H1/genética; Biomarcadores Tumorais/genética; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; Antígenos HLA; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Mutação

Palavras-chave

HED; HLA-I diversity; HLA-I evolutionary divergence; Non-small cell lung cancer; PD-1 immunotherapy; TSO500; Tumor mutational burden

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article

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